via Autop. Luis A. Ferré/PR-52 and Carr Puerto Rico 2 O/PR-2 W Fastest route, despite the usual traffic This route has tolls. San Juan Get on Hwy 1 S/PR-1 S in Santurce from PR-26 Follow PR-52 and Carr Puerto Rico 2 O/PR-2 W to C. Carmelo Martínez in Mayagüez Pueblo, Mayagüez. Take the Calle Carmelo Martínez exit from Carr Puerto Rico 2 O/PR-2 W Drive to C. José de Diego/C. José de Diego Oeste 42-28 C. José de Diego Oeste