Access Expreso Luis Muñoz Rivera/PR-1 S in Santurce from C. de la Luna and Av. Juan Ponce de León. 11 min (4.2 km). Take Highway José de Diego/PR-22 W towards Highway 149/PR-149 in Manatí. Take exit 48 of the Autop. José de Diego/PR-22 W. 33 min (48.1 km). Take Carr Puerto Rico 2 O/PR-2 W, PR-6685 and PR-642 towards PR-641.