Exit the Expreso 22 onto Avenida Kennedy heading south towards San Juan. Continue on Avenida Kennedy until you reach Avenida Ponce de León. Turn right onto Avenida Ponce de León and continue for several blocks. Look for signs indicating the exit or turns towards Río Piedras. You might need to turn left onto Calle de la Cruz or Calle Aurora. Navigate through the streets of Río Piedras towards the urban center. Key streets in Río Piedras include Calle Padre Las Casas and Avenida Domenech.