via Autop. José de Diego/PR-22 W Best route now due to traffic conditions This route has tolls. San Juan Get on Hwy 1 S/PR-1 S in Santurce from C. de la Luna, PR-25 and PR-26 Take Autop. José de Diego/PR-22 W to PR-149 in Manatí. Take exit 48 from Autop. José de Diego/PR-22 W Follow PR-149, Carr Puerto Rico 2 O/PR-2 W and Calle Marginal to Villa Maria in Manatí Villa Maria